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Social work with people with Alzheimers disease
POLACHOVÁ, Kateřina
A bachelor thesis focucses on communication issues with people with Alzheimer´s disease from the point of view of social work. It´s divided on two sections - theoretical and practical. I describe characteristics, symptoms and risk factors with Alzheimer´s disease in theoretical part. I describe problems communication issues social workers, carer and families with clients with Alzheimer´s disease. A practical section includes a research questioning method. I find out if communication is important in social work with people with Alzheimer´s disease and which problems have. I ask two social sanitary facilities which provide complete complex services to clients with Alzheimer´s disease.
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Biological determinations of cognitive disorders
Vítek, Petr ; Šivicová, Gabriela (advisor) ; Stehlík, Luděk (referee)
As a topic of my bachelor thesis I have chosen "Biological determinants of cognitive disorders". Because of the bachelor thesis' coverage I was forced to choose only two cognitive functions - memory and thinking. This work as a whole is an attempt to combine psychological theories with neurological and psychiatric knowledge which are now popular thanks to the rapid development of imaging techniques of brain. One chapter is specifically focused on their brief summary. In the beginning specific cognitive functions are circumscribed but only two of them are taken further - memory and thinking. More space is dedicated to memory because neurological research of memory is much more complex compared to thinking. My approach is similar in both cognitive functions - at first I focus on description of normal functioning and then I classify and describe specific disorders, trying to find their neurological correlations. The second part of my bachelor thesis proposes the research of episodic memory, in which I would compare differences in its distortions from both neurological and neuropsychological perspective. Patients with delusions, pseudologia fantastica and patients with often confabulations are the target group. I tried to create as realistic design as possible. However I realize its financial...
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The effect of immunosupression on cell therapy in mouse model of Alzeimer's disease
Gajdoš, Roman ; Jendelová, Pavla (advisor) ; Chmelová, Martina (referee)
Alzheimer's disease is a chronic, progressive, neurodegenerative disease. It belongs to the most common type of dementia and worldwide it is statistically the fifth cause of mortality. The most common morphological markers are insoluble β amyloid plaques, hyperphosforylated tau proteins and formation of neurofibrilar tangles. Among the manifestations of the disease is amyloid angiopathy, synaptic transmission disorders and subsequent apoptosis, deterioration of cognitive functions and brain atrophy. Studies have shown that administration of mesenchymal stem cells (MSC) has an immunomodulatory effects and it can reduce the production and storage of β amyloid and thus improve cognitive functions. In preclinical studies, which are conducted in transgenic mice and often use xenografts, administration of immunosuppresion may lead to variety of positive or negative effects which can affect the results of the experiment. The subject of the master's thesis was to determine the effect of immunosuppression on experimental therapy with MSC in various time windows of AD progression (model 3xTg). At which scale and combination of immunosupression will influence the cell therapy's effects, the length of graft survival, mortality of experimental animals and changes at the cellular level. We have also assessed...
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The effect of immunosupression on cell therapy in mouse model of Alzeimer's disease
Gajdoš, Roman ; Jendelová, Pavla (advisor) ; Chmelová, Martina (referee)
Alzheimer's disease is a chronic, progressive, neurodegenerative disease. It belongs to the most common type of dementia and worldwide it is statistically the fifth cause of mortality. The most common morphological markers are insoluble β amyloid plaques, hyperphosforylated tau proteins and formation of neurofibrilar tangles. Among the manifestations of the disease is amyloid angiopathy, synaptic transmission disorders and subsequent apoptosis, deterioration of cognitive functions and brain atrophy. Studies have shown that administration of mesenchymal stem cells (MSC) has an immunomodulatory effects and it can reduce the production and storage of β amyloid and thus improve cognitive functions. In preclinical studies, which are conducted in transgenic mice and often use xenografts, administration of immunosuppresion may lead to variety of positive or negative effects which can affect the results of the experiment. The subject of the master's thesis was to determine the effect of immunosuppression on experimental therapy with MSC in various time windows of AD progression (model 3xTg). At which scale and combination of immunosupression will influence the cell therapy's effects, the length of graft survival, mortality of experimental animals and changes at the cellular level. We have also assessed...
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Clinical utility of Rivermead Behavioral Memory Test in Patients after Brain Damage
Šimková, Klára ; Krivošíková, Mária (advisor) ; Bolceková, Eva (referee)
OF DIPLOMA THESIS Title of diploma thesis: Clinical Utility of Rivermead Behavioural Memory Test in Patients after Brain Damage Objective: The main goal of this diploma thesis was to monitor the relationship between memory functions measured by the Rivermead Behavioral Memory Test (RBMT-3) and their subsequent influence on occupational performance in ADL (pADL) in patients after brain damage. The partial objective was to determine whether self-sufficiency in ADL can be predicted from RBMT-3 results. The last partial goal was to create a working version of the RBMT-3 and translate it from the original English version. Methods: The research group consisted of 40 probands (22 males and 18 females) after brain damage. For data collection, the Rivermead Behavioral Memory Test (RBMT-3) for assessing the memory function level was used. FIM (version 5.2) was used for evaluating the level of occupational performance in ADL (pADL). Hypothesis verification was performed by correlation analysis and corrected Spearman's correlation coefficient and p-values. For this pre- research, the level of significance α1 < 0.05 and α2 < 0.01 was chosen. Results: The pre-research did not confirm the dependence between the RBMT-3 memory level and the level of self-sufficiency measured by FIM. The P value (p = 0.526) from the...
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Clinical utility of Rivermead Behavioral Memory Test in Patients after Brain Damage
Šimková, Klára ; Krivošíková, Mária (advisor) ; Bolceková, Eva (referee)
OF DIPLOMA THESIS Title of diploma thesis: Clinical Utility of Rivermead Behavioural Memory Test in Patients after Brain Damage Objective: The main goal of this diploma thesis was to monitor the relationship between memory functions measured by the Rivermead Behavioral Memory Test (RBMT-3) and their subsequent influence on occupational performance in ADL (pADL) in patients after brain damage. The partial objective was to determine whether self-sufficiency in ADL can be predicted from RBMT-3 results. The last partial goal was to create a working version of the RBMT-3 and translate it from the original English version. Methods: The research group consisted of 40 probands (22 males and 18 females) after brain damage. For data collection, the Rivermead Behavioral Memory Test (RBMT-3) for assessing the memory function level was used. FIM (version 5.2) was used for evaluating the level of occupational performance in ADL (pADL). Hypothesis verification was performed by correlation analysis and corrected Spearman's correlation coefficient and p-values. For this pre- research, the level of significance α1 < 0.05 and α2 < 0.01 was chosen. Results: The pre-research did not confirm the dependence between the RBMT-3 memory level and the level of self-sufficiency measured by FIM. The P value (p = 0.526) from the...
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Memory disorders assessment in patients with Alzheimer's disease Subtitle: Relationship between memory disorders and selected Activities of Daily Living
Košnarová, Lenka ; Krivošíková, Mária (advisor) ; Piťhová, Zuzana (referee)
THESIS ABSTRACT Name: Bc. Lenka Košnarová Supervisor: Mária Krivošíková, M.Sc. Opponent: Title of thesis: Memory disorders assessment in patients with Alzheimer's disease Abstract: Objective: The main objective of the thesis was to investigate the impact of memory disorders on self-care in patients with Alzheimer's disease (AD). Another objective of the thesis was to determine whether age of patients with AD affects occupational performance in daily living activities. Methods: The sample was consist of 50 probands (11 men, 39 women), who were diagnosed AD by physician. For data collection was used a questionnaire Bristol Activities of Daily Living scale (BADLS) evaluating self-care and Contextual Memory Test (CMT) for evaluation of memory disorders. Testing the hypothesis was performed by correlation the corrected Spearman correlation coefficient and regression analysis. Results: The thesis results confirmed a significant correlation between BADLS scores and CMT scores - immediate recall (rSp = .51; p<0.05), delay recall (rSp = .42; p<0.05), total (rSp = .48; p<0.05). Furthermore, research results suggest that memory impairment occur more with PADLS. There also was no statistically significant relationship between age and performance of activities of daily living (ADL) coefficient (rSp = .07; p<0.05)....
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